Colour-responsive fluorescent oxy radical sensors

Org Biomol Chem. 2012 Mar 7;10(9):1775-84. doi: 10.1039/c2ob06825g. Epub 2012 Jan 5.


A series of fluorene-fused benzoquinones (Q1-Q5) were prepared by thermolysis of 4-fluorenyl-4-hydroxycyclobutenones. Red fluorescence observed for Q2 is switched by reduction to blue fluorescence by formation of the hydroquinone. Reaction with hydrogen peroxide restores the original fluorescence colour. The potential use of compound Q2 as a reactive oxygen species detector is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzoquinones / chemistry
  • Color
  • Cyclization
  • Fluorescent Dyes / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Reactive Oxygen Species / chemistry*


  • Benzoquinones
  • Fluorescent Dyes
  • Reactive Oxygen Species
  • quinone