LTBPs, more than just an escort service

J Cell Biochem. 2012 Feb;113(2):410-8. doi: 10.1002/jcb.23385.


Latent transforming growth factor beta (TGF-β) binding proteins (LTBPs) are large extracellular glycoproteins structurally similar to fibrillins. They perform intricate and important roles in the extracellular matrix (ECM) and perturbations of their function manifest as a wide range of diseases. LTBPs are major regulators of TGF-β bioavailability and action. In addition, LTBPs interact with other ECM proteins-from cytokines to large multi-factorial aggregates like microfibrils and elastic fibers, affecting their genesis, structure, and performance. In the present article, we review recent advancements in the field and relate the complex roles of LTBP in development and homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Extracellular Matrix / metabolism
  • Genetic Diseases, Inborn / genetics
  • Humans
  • Latent TGF-beta Binding Proteins / chemistry
  • Latent TGF-beta Binding Proteins / genetics
  • Latent TGF-beta Binding Proteins / metabolism*
  • Mutation
  • Protein Binding
  • Protein Structure, Tertiary


  • Latent TGF-beta Binding Proteins