Regulation of DNA replication during development

Development. 2012 Feb;139(3):455-64. doi: 10.1242/dev.061838.


As development unfolds, DNA replication is not only coordinated with cell proliferation, but is regulated uniquely in specific cell types and organs. This differential regulation of DNA synthesis requires crosstalk between DNA replication and differentiation. This dynamic aspect of DNA replication is highlighted by the finding that the distribution of replication origins varies between differentiated cell types and changes with differentiation. Moreover, differential DNA replication in some cell types can lead to increases or decreases in gene copy number along chromosomes. This review highlights the recent advances and technologies that have provided us with new insights into the developmental regulation of DNA replication.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • DNA Helicases / metabolism
  • DNA Replication / genetics*
  • DNA Replication Timing / genetics
  • Drosophila / genetics
  • Drosophila / growth & development
  • Female
  • Gene Amplification
  • Humans
  • Male
  • Mice
  • Morphogenesis / genetics*
  • Origin Recognition Complex / metabolism


  • Origin Recognition Complex
  • DNA Helicases