Trophoblast development

Reproduction. 2012 Mar;143(3):231-46. doi: 10.1530/REP-11-0374. Epub 2012 Jan 5.


This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies, in vivo loss-of-function models and in vitro systems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene regulatory networks. While trophoblast differentiation is quite distinct between cattle and mice, as would be expected from their different modes of implantation, recent studies have demonstrated that differences arise much earlier during trophoblast development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cattle
  • Cell Differentiation* / genetics
  • Cell Differentiation* / physiology
  • Cell Lineage / genetics
  • Cell Lineage / physiology
  • Cell Proliferation
  • Gene Regulatory Networks / genetics
  • Gene Regulatory Networks / physiology
  • Genes, Developmental / physiology
  • Mice
  • Models, Biological
  • Trophoblasts / metabolism
  • Trophoblasts / physiology*