Abstract
Interferon (IF) induction and antiviral activity by purified spherical (S) or filamentous (F) virus-like particles and S-derived RNA was studied. A single administration of S particles prior to virus challenge reduced significantly the mortality of mice infected with western equine encephalitis (WEE) virus.
MeSH terms
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Agaricales*
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Animals
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Cell Line
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Cytopathogenic Effect, Viral
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Encephalitis Virus, Western Equine
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Interferons / biosynthesis
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Male
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Mice
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Plant Viruses / growth & development*
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Plant Viruses / ultrastructure
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RNA, Viral / analysis
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RNA, Viral / pharmacology
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Vesicular stomatitis Indiana virus / growth & development
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Viral Interference*