Model study of the enzymatic modification of natural extracts: peroxidase-based removal of eugenol from rose essential oil

J Agric Food Chem. 2012 Feb 1;60(4):1052-8. doi: 10.1021/jf205194v. Epub 2012 Jan 23.


A protocol based on the use of horseradish peroxidase (HRP) is proposed for the removal of allergenic eugenol from rose essential oil without loss of the organoleptic quality and with a good conservation of the chemical composition. For the first time, an enzyme-based strategy is proposed for essential oils treatment and opens new opportunities in the detoxification of natural extracts used in perfumery and cosmetics. Our results on eugenol in rose essential oil constitute a first step toward the development of efficient and mild processes for the removal of more toxic compounds of natural extracts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Contamination / prevention & control
  • Eugenol / chemistry
  • Eugenol / isolation & purification
  • Eugenol / metabolism*
  • Horseradish Peroxidase / metabolism*
  • Humans
  • Oils, Volatile / chemistry*
  • Oxidation-Reduction
  • Perfume / chemistry
  • Rosa / chemistry*
  • Smell


  • Oils, Volatile
  • Perfume
  • Eugenol
  • Horseradish Peroxidase