Human Immunodeficiency Virus-Associated Psoriasis, Psoriatic Arthritis, and Reiter's Syndrome: A Disease Continuum?

Arthritis Rheum. 1990 Oct;33(10):1574-8. doi: 10.1002/art.1780331016.


The presence of peripheral arthritis and HLA-A, B, C, DR, and DQ antigens was evaluated prospectively in 18 Caucasian men with human immunodeficiency virus-associated psoriasis. An asymmetric polyarthritis occurred in 32% of the patients and correlated with the presence of HLA-B27. Extensive clinical overlap between psoriatic arthritis, psoriasis, and Reiter's syndrome was noted. No significant excess of the HLA antigens previously found to be associated with psoriasis was seen, which suggests that human immunodeficiency virus-associated psoriasis per se may instead constitute another form of spondylarthropathy that is more closely related to Reiter's syndrome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / epidemiology
  • Adult
  • Amino Acid Sequence
  • Amino Acids / analysis
  • Amino Acids / genetics
  • Arthritis, Psoriatic / complications*
  • Arthritis, Psoriatic / epidemiology
  • Arthritis, Reactive / complications*
  • Arthritis, Reactive / epidemiology
  • Gene Frequency / genetics
  • Gene Frequency / immunology
  • HLA Antigens / analysis
  • HLA Antigens / genetics
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Prospective Studies
  • Psoriasis / complications*
  • Psoriasis / epidemiology


  • Amino Acids
  • HLA Antigens