Accurate prediction of cardiorespiratory fitness using cycle ergometry in minimally disabled persons with relapsing-remitting multiple sclerosis

Arch Phys Med Rehabil. 2012 Mar;93(3):490-5. doi: 10.1016/j.apmr.2011.08.025. Epub 2012 Jan 5.


Objective: To examine the accuracy of predicting peak oxygen consumption (VO(2peak)) primarily from peak work rate (WR(peak)) recorded during a maximal, incremental exercise test on a cycle ergometer among persons with relapsing-remitting multiple sclerosis (RRMS) who had minimal disability.

Design: Cross-sectional study.

Setting: Clinical research laboratory.

Participants: Women with RRMS (n=32) and sex-, age-, height-, and weight-matched healthy controls (n=16) completed an incremental exercise test on a cycle ergometer to volitional termination.

Intervention: Not applicable.

Main outcome measures: Measured and predicted VO(2peak) and WR(peak).

Results: There were strong, statistically significant associations between measured and predicted VO(2peak) in the overall sample (R(2)=.89, standard error of the estimate=127.4 mL/min) and subsamples with (R(2)=.89, standard error of the estimate=131.3 mL/min) and without (R(2)=.85, standard error of the estimate=126.8 mL/min) multiple sclerosis (MS) based on the linear regression analyses. Based on the 95% confidence limits for worst-case errors, the equation predicted VO(2peak) within 10% of its true value in 95 of every 100 subjects with MS.

Conclusions: Peak VO(2) can be accurately predicted in persons with RRMS who have minimal disability as it is in controls by using established equations and WR(peak) recorded from a maximal, incremental exercise test on a cycle ergometer.

MeSH terms

  • Adult
  • Bicycling
  • Cross-Sectional Studies
  • Disabled Persons / rehabilitation*
  • Ergometry / methods*
  • Ergometry / statistics & numerical data
  • Exercise Test / methods*
  • Exercise Tolerance
  • Female
  • Heart Rate
  • Humans
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / physiopathology*
  • Multiple Sclerosis, Relapsing-Remitting / rehabilitation*
  • Oxygen Consumption
  • Physical Fitness / physiology*
  • Reproducibility of Results