Respiratory disease in common variable immunodeficiency and other primary immunodeficiency disorders

Clin Radiol. 2012 Jun;67(6):587-95. doi: 10.1016/j.crad.2011.10.028. Epub 2012 Jan 9.


Respiratory disease is a significant cause of morbidity and mortality amongst patients with primary immunodeficiency disorders. Computed tomography (CT) plays an important role in the multidisciplinary approach to these conditions, in detecting, characterizing, and quantifying the extent of lung damage and in directing treatment. The aim of this review is to classify the primary immunodeficiency disorders and describe the thoracic complications and the associated CT findings whilst discussing the role of radiology in diagnosis and surveillance.

Publication types

  • Review

MeSH terms

  • Adult
  • Common Variable Immunodeficiency / complications
  • Common Variable Immunodeficiency / diagnostic imaging*
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunologic Deficiency Syndromes / complications
  • Immunologic Deficiency Syndromes / diagnostic imaging
  • Lung / diagnostic imaging
  • Male
  • Middle Aged
  • Respiratory Tract Diseases / complications
  • Respiratory Tract Diseases / diagnostic imaging*
  • Tomography, X-Ray Computed / methods