Diets rich in fruits and vegetables suppress blood biomarkers of metabolic stress in overweight women

Prev Med. 2012 May;54 Suppl:S109-15. doi: 10.1016/j.ypmed.2011.12.026. Epub 2011 Dec 29.


Objective: This study was performed to evaluate the effects of high vegetable-fruit (high-VF) and low vegetable-fruit (low-VF) diet on surrogate biomarkers of adiposity-related metabolic disturbances.

Methods: Overweight women (n=22, 19-29 years) participated in the study between July and August, 2007 in Seoul, Korea. The intervention consisted of either high-VF diet (12 servings of VF/day) or low-VF diet (2 servings of VF/day). Plasma concentration of carotenoids and biomarkers of inflammation and oxidative stress were determined before and after each intervention period.

Results: Study results indicated that body fat content is positively correlated with plasma interleukin (IL)-6, C-reactive protein (CRP), and leptin concentrations at baseline. Oxidative DNA damage and lipopolysaccharide (LPS)-activated production of IL-1β and IL-6 in peripheral blood mononuclear cells (PBMCs) were decreased with high-VF diet while low-VF diet increased those markers. Changes in the concentration of plasma total carotenoid and β-carotene were inversely correlated with change in plasma IL-1β concentration. Differences in IL-β production in LPS-activated PBMCs were inversely correlated with changes in plasma concentration of lutein-zeaxanthin. Also, changes in plasma total carotenoid and lycopene concentration were inversely correlated with the changes in IL-6 production in LPS-activated PBMCs.

Conclusion: Daily intake of vegetables and fruits can modify adiposity-related metabolic disturbances.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood*
  • Diet*
  • Female
  • Fruit / metabolism*
  • Humans
  • Overweight*
  • Stress, Physiological / physiology*
  • Vegetables / metabolism*
  • Young Adult


  • Biomarkers