Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma

J Clin Neurosci. 2012 Feb;19(2):336-8. doi: 10.1016/j.jocn.2011.05.026. Epub 2012 Jan 9.


We present a patient with type B2 thymoma (World Health Organization Thymoma Classification) with the complications of anti-muscle acetylcholine receptor antibody-positive myasthenia gravis and anti-voltage-gated potassium channel antibodies associated with paraneoplastic encephalitis. A timing difference between the onset of these neurological disorders and a dissociation of clinical symptoms was observed during the disease. This report alerts clinicians that long-term follow-up is needed where patients have a residual thymoma and attention should be paid to other concomitant autoimmune disorders.

MeSH terms

  • Encephalitis / complications
  • Encephalitis / diagnosis*
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Myasthenia Gravis / complications
  • Myasthenia Gravis / diagnosis*
  • Paraneoplastic Syndromes, Nervous System / complications
  • Paraneoplastic Syndromes, Nervous System / diagnosis*
  • Thymoma / complications
  • Thymoma / diagnosis*
  • Thymus Neoplasms / complications
  • Thymus Neoplasms / diagnosis*