Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test

World J Gastroenterol. 2012 Jan 7;18(1):44-8. doi: 10.3748/wjg.v18.i1.44.

Abstract

Aim: To investigate the effects of proton pump inhibitor (PPI) treatment on stool antigen test using the TestMate pylori enzyme immunoassay.

Methods: This study assessed 28 patients [16 men and 12 women; mean age (63.1 ± 5.9) years; range, 25-84 years] who underwent stool antigen test and urea breath test (UBT) before and after PPI administration.

Results: Using the UBT as the standard, the sensitivity, specificity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were significantly lower after than before 4 wk of PPI treatment (12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048). The mean optical density (A(450/630)) ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment (P = 0.989), and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for > 4 wk (P = 0.099).

Conclusion: The stool antigen test was equally sensitive to the UBT, making it a useful and reliable diagnostic method, even during PPI administration.

Keywords: Helicobacter pylori; Proton pump inhibitor; Stool antigen test; Urea breath test.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Bacterial*
  • Breath Tests / methods
  • Feces / microbiology*
  • Female
  • Helicobacter Infections / diagnosis*
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / immunology
  • Humans
  • Immunoenzyme Techniques / methods
  • Immunoenzyme Techniques / standards
  • Male
  • Middle Aged
  • Proton Pump Inhibitors / therapeutic use*
  • Sensitivity and Specificity
  • Urea

Substances

  • Antigens, Bacterial
  • Proton Pump Inhibitors
  • Urea