The many roles of PTK7: a versatile regulator of cell-cell communication

Arch Biochem Biophys. 2012 Aug 1;524(1):71-6. doi: 10.1016/ Epub 2012 Jan 3.


PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor with functions in various processes ranging from embryonic morphogenesis to epidermal wound repair. Here, we review recent findings indicating that PTK7 is a versatile co-receptor that functions as a molecular switch in Wnt, Semaphorin/Plexin and VEGF signaling pathways. We focus in particular on the role of PTK7 in Wnt signaling, as recent data indicate that PTK7 acts as a Wnt co-receptor, which activates the planar cell polarity pathway, but inhibits canonical Wnt signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Communication*
  • Cell Polarity
  • Humans
  • Matrix Metalloproteinases / metabolism
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptors, Vascular Endothelial Growth Factor / metabolism
  • Signal Transduction
  • Wnt Proteins / metabolism*


  • Wnt Proteins
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Vascular Endothelial Growth Factor
  • Matrix Metalloproteinases