The Challenge of Post-Implementation Surveillance for Novel Meningococcal Vaccines

Vaccine. 2012 May 30;30 Suppl 2:B67-72. doi: 10.1016/j.vaccine.2011.12.126. Epub 2012 Jan 9.


Novel serogroup B meningococcal vaccines are currently in late stage development and may be used in mass immunisation campaigns over the coming years. This represents an exciting development in the prevention of childhood meningitis, however monitoring the impact of these vaccines on meningococcal disease epidemiology will provide significant challenges. Although designed to prevent serogroup B meningococcal disease the vaccine antigens are not serogroup specific, creating the potential for multiple definitions of vaccine effectiveness and vaccine failure.

Publication types

  • Review

MeSH terms

  • Humans
  • Meningococcal Infections / epidemiology*
  • Meningococcal Infections / prevention & control*
  • Meningococcal Vaccines / administration & dosage*
  • Meningococcal Vaccines / immunology*
  • Neisseria meningitidis, Serogroup B / isolation & purification*
  • Product Surveillance, Postmarketing / methods
  • Sentinel Surveillance*


  • Meningococcal Vaccines