SLE in 2011: Deciphering the role of NETs and networks in SLE

Nat Rev Rheumatol. 2012 Jan 10;8(2):68-70. doi: 10.1038/nrrheum.2011.200.

Abstract

From neutrophil extracellular traps to genetic networks that underlie the disease and new targeted therapies, important advances in 2011 improve our understanding of the pathogenesis of systemic lupus erythematosus and mark the beginning of our ability to treat it effectively.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Extracellular Space / drug effects
  • Extracellular Space / immunology*
  • Humans
  • Lupus Erythematosus, Systemic* / genetics
  • Lupus Erythematosus, Systemic* / immunology
  • Lupus Erythematosus, Systemic* / therapy
  • Molecular Targeted Therapy / methods*
  • Neutrophils / drug effects
  • Neutrophils / immunology*
  • Phagocytosis / physiology

Substances

  • Antibodies, Monoclonal