Does fingolimod in multiple sclerosis patients cause macular edema?

J Neurol. 2012 Feb;259(2):386-8. doi: 10.1007/s00415-011-6367-4. Epub 2012 Jan 10.

Abstract

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system and is the common cause of optic neuritis. Fingolimod, an immunosuppressive agent, is used in MS to prevent acute exacerbations. We report a case of relapsing-remitting MS treated with fingolimod. The patient presented with an acute decrease in vision in the left eye. Eye examination showed clinical macular edema (ME) in the left eye, which was confirmed on fluorescein angiogram and optical coherence tomography (OCT). After discontinuation of fingolimod and treatment with topical corticosteroid medication, there was complete resolution of the ME. The ME as a side-effect of fingolimod is reversible after discontinuing, which was seen on OCT.

Publication types

  • Case Reports

MeSH terms

  • Fingolimod Hydrochloride
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Macular Edema / chemically induced*
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Propylene Glycols / adverse effects*
  • Sphingosine / adverse effects
  • Sphingosine / analogs & derivatives*
  • Tomography, Optical Coherence

Substances

  • Immunosuppressive Agents
  • Propylene Glycols
  • Fingolimod Hydrochloride
  • Sphingosine