Dynamin, a Membrane-Remodelling GTPase

Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88. doi: 10.1038/nrm3266.

Abstract

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our understanding of the mechanisms by which dynamin acts, its essential roles in cell physiology and the specific function of different dynamin isoforms. In addition, several connections between dynamin and human disease have also emerged, highlighting specific contributions of this GTPase to the physiology of different tissues.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Cell Membrane / physiology*
  • Dynamins / chemistry
  • Dynamins / genetics
  • Dynamins / metabolism
  • Dynamins / physiology*
  • Endocytosis / genetics
  • Endocytosis / physiology
  • GTP Phosphohydrolases / chemistry
  • GTP Phosphohydrolases / genetics
  • GTP Phosphohydrolases / metabolism
  • GTP Phosphohydrolases / physiology
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Isoenzymes / physiology
  • Mammals / genetics
  • Mammals / metabolism
  • Membrane Fluidity / genetics
  • Mice
  • Models, Biological
  • Models, Molecular
  • Protein Conformation

Substances

  • Isoenzymes
  • GTP Phosphohydrolases
  • Dynamins

Associated data

  • PDB/3SNH