Cancer-associated isocitrate dehydrogenase mutations

Oncologist. 2012;17(1):5-8. doi: 10.1634/theoncologist.2011-0429. Epub 2012 Jan 10.

Abstract

The role of isocitrate dehydrogenase mutations as a therapeutic target for cancer therapy is examined.

Publication types

  • Comment

MeSH terms

  • Bile Duct Neoplasms / genetics*
  • Bile Ducts, Intrahepatic / pathology*
  • Cholangiocarcinoma / genetics*
  • Female
  • Gallbladder Neoplasms / genetics*
  • Humans
  • Isocitrate Dehydrogenase / genetics*
  • Male
  • Mutation*

Substances

  • Isocitrate Dehydrogenase
  • isocitrate dehydrogenase 2, human
  • IDH1 protein, human