Ketamine-like effects after recreational use of methoxetamine

Ann Emerg Med. 2012 Jul;60(1):97-9. doi: 10.1016/j.annemergmed.2011.11.018. Epub 2012 Jan 10.


Methoxetamine, the N-ethyl derivative of ketamine, is a novel recreational drug that is not at present subject to restrictive regulations in most countries. To our knowledge, no case of methoxetamine abuse has been published to date in the scientific literature, and the only sources of information are illegal drug users' Web discussion forums. We report the first case of analytically confirmed intravenous methoxetamine abuse in a 19-year-old man. Observed signs and symptoms such as tachycardia, hypertension, confusion, agitation, stupor, ataxia, mydriasis, and nystagmus were consistent with ketamine-induced adverse effects and resolved with symptomatic treatment. According to this case report, user Web reports, and the chemical structure, methoxetamine produces ketamine-like effects. Complete recovery can be expected with supportive care.

Publication types

  • Case Reports

MeSH terms

  • Anesthetics, Dissociative / adverse effects
  • Confusion / chemically induced
  • Cyclohexanones / poisoning*
  • Cyclohexylamines / poisoning*
  • Dyskinesias / etiology
  • Humans
  • Hypertension / chemically induced
  • Illicit Drugs / poisoning*
  • Ketamine / adverse effects
  • Male
  • Mydriasis / chemically induced
  • Nystagmus, Pathologic / chemically induced
  • Tachycardia / chemically induced
  • Young Adult


  • Anesthetics, Dissociative
  • Cyclohexanones
  • Cyclohexylamines
  • Illicit Drugs
  • Ketamine
  • 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone