Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion

J Cancer Res Clin Oncol. 2012 Apr;138(4):671-4. doi: 10.1007/s00432-012-1147-9. Epub 2012 Jan 12.


Backgrounds: microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established. In this study, we investigated the expression of microRNA-218 in the sera from cervical cancer patients and its relationships with clinico-pathological characteristics.

Methods: The expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR. The clinical data were collected and analyzed by statistical software.

Results: In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis.

Conclusions: microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / blood
  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Lymphatic Metastasis
  • MicroRNAs / blood
  • MicroRNAs / genetics*
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Reverse Transcriptase Polymerase Chain Reaction
  • Uterine Cervical Neoplasms / blood
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / pathology*


  • MIRN218 microRNA, human
  • MicroRNAs