[Experience of cytoflavin administration for treating acute carbon monoxide poisoning]

Eksp Klin Farmakol. 2011;74(10):39-42.
[Article in Russian]

Abstract

Results of an analysis of the efficiency of using cytoflavin, a drug possessing cytoprotective and antihypoxemic properties, in a group of 215 patients with a diagnosis of acute carbon monoxide poisoning in 2004-2010 are compared to analogous data for 215 patients with same diagnosis treated in 1999-2004 without cytoflavin administration. It is established that timely application of cytoflavin (against the standard treatment of CO poisoning) favored lower expressiveness of post-hypoxemic encephalopathythatis characteristic of the given pathology.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Carbon Monoxide / adverse effects*
  • Carbon Monoxide Poisoning / complications
  • Carbon Monoxide Poisoning / drug therapy*
  • Carbon Monoxide Poisoning / mortality
  • Carbon Monoxide Poisoning / physiopathology
  • Carboxyhemoglobin / analysis
  • Carboxyhemoglobin / antagonists & inhibitors*
  • Carboxyhemoglobin / metabolism
  • Case-Control Studies
  • Drug Administration Schedule
  • Drug Combinations
  • Female
  • Flavin Mononucleotide / administration & dosage
  • Flavin Mononucleotide / therapeutic use*
  • Humans
  • Hypoxia / complications
  • Hypoxia / drug therapy*
  • Hypoxia / mortality
  • Hypoxia / physiopathology
  • Infusions, Intravenous
  • Inosine Diphosphate / administration & dosage
  • Inosine Diphosphate / therapeutic use*
  • Male
  • Middle Aged
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / therapeutic use*
  • Niacinamide / administration & dosage
  • Niacinamide / therapeutic use*
  • Retrospective Studies
  • Russia
  • Severity of Illness Index
  • Succinates / administration & dosage
  • Succinates / therapeutic use*
  • Survival Rate
  • Unconsciousness / prevention & control*

Substances

  • Drug Combinations
  • Neuroprotective Agents
  • Succinates
  • cytoflavin
  • Niacinamide
  • Flavin Mononucleotide
  • Carbon Monoxide
  • Inosine Diphosphate
  • Carboxyhemoglobin