Nutrition strategies to improve physical capabilities in Duchenne muscular dystrophy

Phys Med Rehabil Clin N Am. 2012 Feb;23(1):187-99, xii-xiii. doi: 10.1016/j.pmr.2011.11.010. Epub 2011 Dec 13.

Abstract

There is no current cure for Duchenne muscular dystrophy (DMD), and palliative and prophylactic interventions to improve the quality of life of patients remain limited, with the exception of corticosteroids. This article describes 2 potential nutritional interventions for the treatment of DMD, green tea extract (GTE) and the branched-chain amino acid leucine, and their positive effects on physical activity. Both GTE and leucine are suitable for human consumption, are easily tolerated with no side effects, and, with appropriate preclinical data, could be brought forward to clinical trials rapidly.

Publication types

  • Review

MeSH terms

  • Animals
  • Camellia sinensis*
  • Dietary Supplements
  • Humans
  • Leucine / therapeutic use*
  • Motor Activity
  • Muscular Dystrophy, Duchenne / drug therapy*
  • Muscular Dystrophy, Duchenne / physiopathology
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Signal Transduction
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • Plant Extracts
  • TOR Serine-Threonine Kinases
  • Leucine