Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

MeSH terms

• Binding Sites / drug effects
• Cross-Linking Reagents / chemical synthesis
• Cross-Linking Reagents / chemistry
• Cross-Linking Reagents / pharmacology*
• Humans
• Jumonji Domain-Containing Histone Demethylases / antagonists & inhibitors*
• Jumonji Domain-Containing Histone Demethylases / chemistry
• Ketoglutaric Acids / chemistry
• Ketoglutaric Acids / pharmacology*
• Models, Molecular
• Molecular Structure
• Structure-Activity Relationship
• Substrate Specificity