Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

Parkinsonism Relat Disord. 2012 May;18(4):391-3. doi: 10.1016/j.parkreldis.2011.12.014. Epub 2012 Jan 12.

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asians
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Genotype
  • HLA-DR alpha-Chains / genetics*
  • Humans
  • Male
  • Meta-Analysis as Topic
  • Middle Aged
  • Odds Ratio
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Reference Values
  • Taiwan
  • Whites
  • Young Adult

Substances

  • HLA-DR alpha-Chains