Abatacept and Sodium Thiosulfate for Treatment of Recalcitrant Juvenile Dermatomyositis Complicated by Ulceration and Calcinosis

J Pediatr. 2012 Mar;160(3):520-2. doi: 10.1016/j.jpeds.2011.11.057. Epub 2012 Jan 13.

Abstract

We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis. This combination therapy resulted in significant reductions in muscle and skin inflammation, decreased corticosteroid dependence, and halted the progression of calcinosis.

Publication types

  • Case Reports
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Abatacept
  • Adolescent
  • Anti-Inflammatory Agents / administration & dosage*
  • Antioxidants / administration & dosage*
  • Calcinosis / complications*
  • Chelating Agents / administration & dosage*
  • Dermatomyositis / complications
  • Dermatomyositis / drug therapy*
  • Dermatomyositis / pathology
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunoconjugates / administration & dosage*
  • Immunosuppressive Agents / administration & dosage*
  • Skin Ulcer / complications*
  • Thiosulfates / administration & dosage*

Substances

  • Anti-Inflammatory Agents
  • Antioxidants
  • Chelating Agents
  • Immunoconjugates
  • Immunosuppressive Agents
  • Thiosulfates
  • Abatacept
  • sodium thiosulfate