Current management of gestational trophoblastic neoplasia

Hematol Oncol Clin North Am. 2012 Feb;26(1):111-31. doi: 10.1016/j.hoc.2011.10.007. Epub 2011 Nov 21.


Gestational trophoblastic neoplasms are malignant lesions that arise from placental villous and extravillous trophoblast. Four clinicopathologic conditions make up this entity: invasive mole (IM), choriocarcinoma (CCA), placental-site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). IM and CCA, which make up the majority of these tumors, are highly responsive to chemotherapy with an overall cure rate exceeding 90%, making it usually possible to achieve cure while preserving reproductive function. PSTT and ETT, which rarely occur, are relatively resistant to chemotherapy, making surgery the primary treatment modality, chemotherapy being used only when the disease has metastasized.

Publication types

  • Review

MeSH terms

  • Central Nervous System Neoplasms / secondary
  • Central Nervous System Neoplasms / therapy
  • Female
  • Follow-Up Studies
  • Gestational Trophoblastic Disease / diagnosis
  • Gestational Trophoblastic Disease / epidemiology
  • Gestational Trophoblastic Disease / therapy*
  • Humans
  • Liver Neoplasms / secondary
  • Liver Neoplasms / therapy
  • Lung Neoplasms / secondary
  • Lung Neoplasms / therapy
  • Neoplasm Staging
  • Pregnancy
  • Pregnancy Complications, Neoplastic / diagnosis
  • Pregnancy Complications, Neoplastic / therapy
  • Risk Assessment