Organized living: formation mechanisms and functions of plasma membrane domains in yeast

Trends Cell Biol. 2012 Mar;22(3):151-8. doi: 10.1016/j.tcb.2011.12.002. Epub 2012 Jan 12.


Plasma membrane proteins and lipids organize into lateral domains of specific composition. Domain formation is achieved by a combination of lipid-lipid and lipid-protein interactions, membrane-binding protein scaffolds and protein fences. The resulting domains function in membrane protein turnover and homeostasis, as well as in cell signaling. We review the mechanisms generating plasma membrane domains and the functional consequences of this organization, focusing on recent findings from research on the yeast model system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism*
  • Fungal Proteins / chemistry
  • Fungal Proteins / metabolism*
  • Homeostasis
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae / metabolism*
  • Signal Transduction


  • Fungal Proteins
  • Membrane Proteins