Non-resective surgery and radiosurgery for treatment of drug-resistant epilepsy

Epilepsy Res. 2012 May;99(3):193-201. doi: 10.1016/j.eplepsyres.2011.12.016. Epub 2012 Jan 13.


Epilepsy surgery is an effective treatment for properly selected patients with intractable seizures. However, many patients with medically intractable epilepsy are not excellent candidates for surgical resection of the epileptogenic zone. Due to recent advances in computer technology and bioengineering, several novel techniques are receiving increasing interest for their role in the care of people with epilepsy. Neuromodulation is an emerging surgical option to be used when conventional resective surgery is not indicated. We review the indications and expected outcomes of neuromodulatory treatments currently available for the treatment of refractory epilepsy, i.e., vagus nerve stimulation, deep brain stimulation, stereotactic radiosurgery, and multiple subpial transections.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticonvulsants / therapeutic use
  • Deep Brain Stimulation / methods*
  • Deep Brain Stimulation / trends
  • Epilepsy / diagnosis
  • Epilepsy / physiopathology
  • Epilepsy / therapy*
  • Humans
  • Radiosurgery / methods*
  • Radiosurgery / trends
  • Treatment Outcome


  • Anticonvulsants