Pulmonary veno-occlusive disease following reduced-intensity allogeneic bone marrow transplantation for acute myeloid leukemia

Intern Med. 2012;51(2):195-8. doi: 10.2169/internalmedicine.51.6302. Epub 2012 Jan 15.


We report a case of pulmonary veno-occlusive disease (PVOD) following allogeneic bone marrow transplantation (BMT) for the treatment of acute myeloid leukemia (AML) from an HLA mismatched mother using a reduced-intensity conditioning (RIC) regimen including gemtuzumab ozogamicin. The patient was a 21-year-old male who complained of dyspnea with hypoxemia followed by loss of consciousness. The abnormalities in chest CT and echocardiography were compatible with a diagnosis of PVOD. Treatment with 1 mg/kg of oral prednisolone resolved dyspnea and hypoxemia within a few days, and chest CT abnormalities disappeared in a week. This report is the first to describe PVOD following RIC stem cell transplantation.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow Transplantation / adverse effects*
  • Diagnosis, Differential
  • Humans
  • Leukemia, Myeloid, Acute / surgery*
  • Male
  • Pulmonary Veno-Occlusive Disease / diagnosis*
  • Pulmonary Veno-Occlusive Disease / etiology
  • Transplantation Conditioning / adverse effects*
  • Young Adult