Role of endoplasmic reticulum stress in metabolic disease and other disorders

Annu Rev Med. 2012;63:317-28. doi: 10.1146/annurev-med-043010-144749.


Perturbations in the normal functions of the endoplasmic reticulum (ER) trigger a signaling network that coordinates adaptive and apoptotic responses. There is accumulating evidence implicating prolonged ER stress in the development and progression of many diseases, including neurodegeneration, atherosclerosis, type 2 diabetes, liver disease, and cancer. With the improved understanding of the underlying molecular mechanisms, therapeutic interventions that target the ER stress response would be potential strategies to treat various diseases driven by prolonged ER stress.

Publication types

  • Review

MeSH terms

  • Apoptosis / physiology*
  • Endoplasmic Reticulum / pathology
  • Endoplasmic Reticulum / physiology*
  • Endoplasmic Reticulum Stress / physiology*
  • Humans
  • Metabolic Diseases / pathology
  • Metabolic Diseases / physiopathology*