The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response

Oncogene. 2012 Nov 8;31(45):4803-9. doi: 10.1038/onc.2011.638. Epub 2012 Jan 16.

Abstract

DNA repair is essential in maintaining genome integrity and defects in different steps of the process have been linked to cancer and aging. It is a long lasting question how DNA repair is spatially and temporarily organized in the highly compartmentalized nucleus and whether the diverse nuclear compartments regulate differently the efficiency of repair. Increasing evidence suggest the involvement of nuclear pore complexes in repair of double-strand breaks (DSBs) in yeast. Here, we show that the human nucleoporin 153 (NUP153) has a role in repair of DSBs and in the activation of DNA damage checkpoints. We explore the mechanism of action of NUP153 and we propose its potential as a novel therapeutic target in cancers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / pharmacology
  • Bleomycin / pharmacology
  • Cell Line
  • Cell Nucleus / metabolism
  • Cell Survival / genetics
  • DNA Breaks, Double-Stranded* / drug effects
  • DNA End-Joining Repair
  • DNA Repair / physiology*
  • Homologous Recombination
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Nuclear Pore Complex Proteins / genetics
  • Nuclear Pore Complex Proteins / metabolism*
  • Protein Transport
  • RNA Interference / drug effects
  • Tumor Suppressor p53-Binding Protein 1

Substances

  • Antibiotics, Antineoplastic
  • Intracellular Signaling Peptides and Proteins
  • NUP153 protein, human
  • Nuclear Pore Complex Proteins
  • TP53BP1 protein, human
  • Tumor Suppressor p53-Binding Protein 1
  • Bleomycin