Diversity within the pRb pathway: is there a code of conduct?

Oncogene. 2012 Oct 4;31(40):4343-52. doi: 10.1038/onc.2011.603. Epub 2012 Jan 16.


The failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle and tumour suppression. Recent findings have revealed new levels of complexity reflecting a repertoire of post-translational modifications that occur on pRb together with its key effector E2F-1. Here we provide an overview of the modifications and consider the possibility of a 'code' that endows pRb with the ability to function in diverse physiological settings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation
  • Apoptosis
  • Cell Cycle / genetics
  • Cell Proliferation
  • E2F1 Transcription Factor / metabolism*
  • Humans
  • Methylation
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Retinoblastoma Protein / metabolism*
  • Signal Transduction
  • Ubiquitination


  • E2F1 Transcription Factor
  • E2F1 protein, human
  • Retinoblastoma Protein