Base excision repair and cancer

doi:10.1016/j.canlet.2011.12.038

Review

. 2012 Dec 31;327(1-2):73-89.

doi: 10.1016/j.canlet.2011.12.038. Epub 2012 Jan 15.

Base excision repair and cancer

Susan S Wallace¹, Drew L Murphy, Joann B Sweasy

Affiliations

Affiliation

¹ Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, 05405-0068, United States. susan.wallace@uvm.edu

PMID: 22252118
PMCID: PMC3361536
DOI: 10.1016/j.canlet.2011.12.038

Free PMC article

Review

Base excision repair and cancer

Susan S Wallace et al. Cancer Lett. 2012.

Free PMC article

. 2012 Dec 31;327(1-2):73-89.

doi: 10.1016/j.canlet.2011.12.038. Epub 2012 Jan 15.

Authors

Susan S Wallace¹, Drew L Murphy, Joann B Sweasy

Affiliation

¹ Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, 05405-0068, United States. susan.wallace@uvm.edu

PMID: 22252118
PMCID: PMC3361536
DOI: 10.1016/j.canlet.2011.12.038

Abstract

Base excision repair is the system used from bacteria to man to remove the tens of thousands of endogenous DNA damages produced daily in each human cell. Base excision repair is required for normal mammalian development and defects have been associated with neurological disorders and cancer. In this paper we provide an overview of short patch base excision repair in humans and summarize current knowledge of defects in base excision repair in mouse models and functional studies on short patch base excision repair germ line polymorphisms and their relationship to cancer. The biallelic germ line mutations that result in MUTYH-associated colon cancer are also discussed.

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Figures

**Figure 1. Short Patch Base Excision Repair**

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References

1. Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA, Ellenberger T. DNA Repair and Mutagenesis. Second Edition ASM Press; Washington, D.C.: 2006.
1. Lindahl T. An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues. Proc Natl Acad Sci U S A. 1974;71:3649–3653. - PMC - PubMed
1. Mitra S, Hazra TK, Roy R, Ikeda S, Biswas T, Lock J, Boldogh I, Izumi T. Complexities of DNA base excision repair in mammalian cells. Mol Cells. 1997;7:305–312. - PubMed
1. Krokan HE, Nilsen H, Skorpen F, Otterlei M, Slupphaug G. Base excision repair of DNA in mammalian cells. FEBS Lett. 2000;476:73–77. - PubMed
1. Mitra S, Izumi T, Boldogh I, Bhakat KK, Hill JW, Hazra TK. Choreography of oxidative damage repair in mammalian genomes. Free Radic Biol Med. 2002;33:15–28. - PubMed

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[1] Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA, Ellenberger T. DNA Repair and Mutagenesis. Second Edition ASM Press; Washington, D.C.: 2006.

[2] Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA, Ellenberger T. DNA Repair and Mutagenesis. Second Edition ASM Press; Washington, D.C.: 2006.

[3] Lindahl T. An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues. Proc Natl Acad Sci U S A. 1974;71:3649–3653. - PMC - PubMed

[4] Lindahl T. An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues. Proc Natl Acad Sci U S A. 1974;71:3649–3653. - PMC - PubMed

[5] Mitra S, Hazra TK, Roy R, Ikeda S, Biswas T, Lock J, Boldogh I, Izumi T. Complexities of DNA base excision repair in mammalian cells. Mol Cells. 1997;7:305–312. - PubMed

[6] Mitra S, Hazra TK, Roy R, Ikeda S, Biswas T, Lock J, Boldogh I, Izumi T. Complexities of DNA base excision repair in mammalian cells. Mol Cells. 1997;7:305–312. - PubMed

[7] Krokan HE, Nilsen H, Skorpen F, Otterlei M, Slupphaug G. Base excision repair of DNA in mammalian cells. FEBS Lett. 2000;476:73–77. - PubMed

[8] Krokan HE, Nilsen H, Skorpen F, Otterlei M, Slupphaug G. Base excision repair of DNA in mammalian cells. FEBS Lett. 2000;476:73–77. - PubMed

[9] Mitra S, Izumi T, Boldogh I, Bhakat KK, Hill JW, Hazra TK. Choreography of oxidative damage repair in mammalian genomes. Free Radic Biol Med. 2002;33:15–28. - PubMed

[10] Mitra S, Izumi T, Boldogh I, Bhakat KK, Hill JW, Hazra TK. Choreography of oxidative damage repair in mammalian genomes. Free Radic Biol Med. 2002;33:15–28. - PubMed

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Base excision repair and cancer

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Base excision repair and cancer

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