Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters

Dhevalapally B Ramachary; Chintalapudi Venkaiah; Patoju Murali Krishna

doi:10.1039/c2cc17219d

Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters

Chem Commun (Camb). 2012 Feb 21;48(16):2252-4. doi: 10.1039/c2cc17219d. Epub 2012 Jan 18.

Authors

Dhevalapally B Ramachary¹, Chintalapudi Venkaiah, Patoju Murali Krishna

Affiliation

¹ School of Chemistry, University of Hyderabad, Hyderabad-500 046, India. ramsc@uohyd.ernet.in

PMID: 22252651
DOI: 10.1039/c2cc17219d

Abstract

We present herein for the first time the asymmetric synthesis of drug-like spiranes through reflexive-Michael reaction by using 2-aminobuta-1,3-enyne catalysis under mild conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry
Catalysis
Chemistry Techniques, Synthetic
Cyclohexanes / chemical synthesis*
Spiro Compounds / chemical synthesis*
Stereoisomerism

Substances

Alkynes
Cyclohexanes
Spiro Compounds