Klebsiella pneumoniae ST258 producing KPC-3 identified in italy carries novel plasmids and OmpK36/OmpK35 porin variants

Antimicrob Agents Chemother. 2012 Apr;56(4):2143-5. doi: 10.1128/AAC.05308-11. Epub 2012 Jan 17.

Abstract

A carbapenemase-resistant Klebsiella pneumoniae strain, clone ST258 producing KPC-3, was fully characterized. The entire plasmid content was investigated, thereby identifying plasmids of the IncFII(k) (two of them similar to pKPQIL and pKPN3, respectively), IncX, and ColE types, carrying a formidable set of resistance genes against toxic compounds, metals, and antimicrobial drugs and a novel iron(III) uptake system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • Drug Resistance, Bacterial / genetics*
  • Genes, Bacterial / genetics
  • Genetic Variation
  • Humans
  • Iron / metabolism
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics*
  • Metals / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Plasmids / genetics*
  • Porins / genetics*
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Metals
  • OmpK35 porin, Klebsiella pneumoniae
  • OmpK36 protein, Klebsiella pneumoniae
  • Porins
  • Iron
  • beta-Lactamases
  • beta-lactamase KPC-3, Klebsiella pneumoniae

Associated data

  • GENBANK/JN233704
  • GENBANK/JN233705
  • GENBANK/JN247852
  • GENBANK/JN247853