Abstract
A carbapenemase-resistant Klebsiella pneumoniae strain, clone ST258 producing KPC-3, was fully characterized. The entire plasmid content was investigated, thereby identifying plasmids of the IncFII(k) (two of them similar to pKPQIL and pKPN3, respectively), IncX, and ColE types, carrying a formidable set of resistance genes against toxic compounds, metals, and antimicrobial drugs and a novel iron(III) uptake system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Drug Resistance, Bacterial / genetics*
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Genes, Bacterial / genetics
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Genetic Variation
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Humans
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Iron / metabolism
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / genetics*
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Metals / pharmacology
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Plasmids / genetics*
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Porins / genetics*
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Metals
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OmpK35 porin, Klebsiella pneumoniae
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OmpK36 protein, Klebsiella pneumoniae
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Porins
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Iron
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beta-Lactamases
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beta-lactamase KPC-3, Klebsiella pneumoniae
Associated data
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GENBANK/JN233704
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GENBANK/JN233705
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GENBANK/JN247852
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GENBANK/JN247853