Flavan-3-ol compounds from wine wastes with in vitro and in vivo antioxidant activity

Nutrients. 2010 Oct;2(10):1048-59. doi: 10.3390/nu2101048. Epub 2010 Oct 11.


It has been suggested that the dietary intake of antioxidant supplements could be a useful strategy to reduce the incidence of diseases associated with oxidative stress. The aim of present work is to study the possibility to obtain compounds with antioxidant activity from wine wastes using water as solvent. Results have shown that it is possible to obtain flavan-3-ol compounds from wine wastes both from V. vinifera (cv. Cabernet Sauvignon and Merlot) and V. labrusca (cv. Bordo and Isabella) species. The main phenolic compounds found in the extracts were catechin and epicatechin, followed by procyanidin B3, procyanidin B1, procyanidin B2, gallic acid, epigallocatechin, and procyanidin B4. All flavan-3-ol extracts showed significant in vitro and in vivo activities. It was found that the extracts were able to prevent lipid and protein oxidative damage in the cerebral cortex, cerebellum and hippocampus tissues of rats. Although further studies are necessary, these flavan-3-ol extracts show potential to be used to reduce the incidence of degenerative diseases associated with oxidative stress.

Keywords: V. labrusca; V. vinifera; antioxidant; aqueous wine waste extracts; phenolic content.

MeSH terms

  • Animals
  • Antioxidants / analysis
  • Antioxidants / pharmacology*
  • Brain / drug effects*
  • Brain / metabolism
  • Flavonoids / analysis
  • Flavonoids / pharmacology*
  • Fruit
  • Lipid Peroxidation / drug effects
  • Oxidative Stress / drug effects*
  • Phenols / analysis
  • Phenols / pharmacology*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Protein Carbonylation / drug effects
  • Rats
  • Rats, Wistar
  • Vitis / chemistry*
  • Wine


  • Antioxidants
  • Flavonoids
  • Phenols
  • Plant Extracts
  • flavan-3-ol