Pyroglutamic aciduria: a cause of high anion-gap metabolic acidosis associated with common drugs

Ir Med J. Nov-Dec 2011;104(10):312-3.

Abstract

Pyroglutamic aciduria is a rare and probably under-recognised cause of metabolic acidosis which may be precipitated by certain common drugs.

MeSH terms

  • Acetaminophen / administration & dosage
  • Acetaminophen / adverse effects*
  • Acid-Base Equilibrium / drug effects*
  • Acidosis / chemically induced*
  • Acidosis / urine
  • Aged, 80 and over
  • Analgesics, Non-Narcotic / administration & dosage
  • Analgesics, Non-Narcotic / adverse effects
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Arthroplasty / adverse effects
  • Drug Monitoring
  • Drug Substitution
  • Female
  • Floxacillin / administration & dosage
  • Floxacillin / adverse effects*
  • Hip Fractures / surgery
  • Humans
  • Pyrrolidonecarboxylic Acid / analysis*
  • Surgical Wound Infection / drug therapy*
  • Surgical Wound Infection / etiology
  • Treatment Outcome
  • Withholding Treatment

Substances

  • Analgesics, Non-Narcotic
  • Anti-Bacterial Agents
  • Acetaminophen
  • Floxacillin
  • Pyrrolidonecarboxylic Acid