Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Feb;28(2):53-7.
doi: 10.1016/j.pt.2011.12.004. Epub 2012 Jan 16.

Virulence Without Catalysis: How Can a Pseudokinase Affect Host Cell Signaling?

Affiliations

Virulence Without Catalysis: How Can a Pseudokinase Affect Host Cell Signaling?

Michael L Reese et al. Trends Parasitol. .

Abstract

A hallmark of the pathogenic lifestyle is the secretion of enzymes and other effectors that dysregulate host signaling. Intriguingly, the most potent virulence locus identified in the intracellular parasite Toxoplasma gondii encodes a family of related catalytically inactive protein kinases, or pseudokinases. Toxoplasma has in its kinome among the highest percentage of pseudokinases among all sequenced organisms, and the majority of these appear to be secreted into the host cell. We posit that the pseudokinase fold represents a particularly well-suited domain for functional diversification, discuss the relevance of gene expansion at these loci, and outline potential mechanisms by which a pseudokinase might affect host signaling.

Similar articles

See all similar articles

Cited by 11 articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback