Are snoRNAs and snoRNA host genes new players in cancer?

Nat Rev Cancer. 2012 Jan 19;12(2):84-8. doi: 10.1038/nrc3195.


Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous elements in the production of the protein synthesis machinery of the cell. Recently, however, several independent lines of evidence have indicated that these non-coding RNAs might have crucial roles in controlling cell behaviour, and snoRNA dysfunction could consequently contribute to oncogenesis in previously unsuspected ways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Neoplasms / genetics*
  • RNA Processing, Post-Transcriptional
  • RNA, Small Nucleolar / genetics*


  • RNA, Small Nucleolar