The Diverse and Complex Roles of NF-κB Subunits in Cancer

Nat Rev Cancer. 2012 Jan 19;12(2):121-32. doi: 10.1038/nrc3204.

Abstract

It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer development has been understood. Although much attention has focused on the upstream pathways leading to NF-κB activation, it is now becoming clear that the inhibitor of NF-κB kinases (IKKs), which regulate NF-κB activation, have many independent functions in tissue homeostasis and normal immune function that could compromise the clinical utility of IKK inhibitors. Therefore, if the NF-κB pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-κB subunits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Genes, Tumor Suppressor
  • Humans
  • NF-kappa B / chemistry
  • NF-kappa B / physiology*
  • Neoplasms / physiopathology*

Substances

  • NF-kappa B