Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

Pediatr Res. 2012 Feb;71(2):205-9. doi: 10.1038/pr.2011.30. Epub 2011 Dec 21.


Introduction: We sought to determine whether 18- to 22-mo neurodevelopmental outcomes predicted functional outcomes at 7-8 y for survivors of the CoolCap study of therapeutic hypothermia for neonates with hypoxic-ischemic encephalopathy.

Results: WeeFIM ratings were completed at 7-8 y of age on 62 (32 cooled; 30 standard care) of 135 surviving children who had had neurodevelopmental assessment at 18 mo. There was 1 refusal, 58 lost to follow-up, and 14 children whose centers declined to participate. Disability status at 18 mo was strongly associated with WeeFIM ratings (P < 0.001); there was no significant effect of treatment (P = 0.83).

Discussion: Functional outcome at 7-8 y of survivors of neonatal encephalopathy is associated with 18-mo neurodevelopmental assessment, supporting the long-term predictive value of a favorable outcome at 18 mo assessed by published trials of therapeutic hypothermia.

Methods: All surviving children who participated in the CoolCap study and were assessed at 18 mo were eligible for reassessment using the WeeFIM instrument that qualitatively measures self-care, mobility, and cognitive function. Center investigators obtained consent from the families for a certified researcher to administer the WeeFIM instrument by phone.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Child
  • Child Development*
  • Cognition
  • Developmental Disabilities / diagnosis
  • Developmental Disabilities / etiology*
  • Developmental Disabilities / physiopathology
  • Developmental Disabilities / psychology
  • Disability Evaluation
  • Female
  • Follow-Up Studies
  • Humans
  • Hypothermia, Induced*
  • Hypoxia-Ischemia, Brain / complications
  • Hypoxia-Ischemia, Brain / mortality
  • Hypoxia-Ischemia, Brain / physiopathology
  • Hypoxia-Ischemia, Brain / psychology
  • Hypoxia-Ischemia, Brain / therapy*
  • Infant, Newborn
  • Logistic Models
  • Male
  • Motor Skills
  • Neuropsychological Tests
  • New Zealand
  • Predictive Value of Tests
  • Self Care
  • Surveys and Questionnaires
  • Treatment Outcome
  • United Kingdom
  • United States