Cognitive function and decline in obesity

J Alzheimers Dis. 2012;30 Suppl 2:S89-95. doi: 10.3233/JAD-2011-111073.

Abstract

Obesity is a significant contemporary health concern that carries wide-ranging implications for society, as well as for individual health and well-being. In particular, the neuropsychological sequelae of obesity carry wide ranging functional implications. While research in this area is growing, our knowledge of obesity-related cognitive dysfunction and brain alterations has not yet been synthesized. The present review integrates the recent literature regarding patterns of obesity-related cognitive dysfunction and brain alterations and also indicates potential mechanisms for these neuropathological changes. The review culminates in a preliminary model of obesity-related cognitive dysfunction and suggestions for future research, including the potential reversibility of these changes with weight-loss.

Publication types

  • Review

MeSH terms

  • Aging
  • Cognition Disorders / diagnosis
  • Cognition Disorders / etiology*
  • Dementia / physiopathology
  • Humans
  • Models, Biological
  • Obesity / complications*
  • Obesity / therapy