Ex vivo measurements of mucus secretion by colon explants

Methods Mol Biol. 2012;842:237-43. doi: 10.1007/978-1-61779-513-8_14.


An explant tissue system for the study and recording of mucus secretion has been developed. Human colon biopsies or tissue from experimental animals are mounted in a horizontal perfusion chamber and the mucus accumulated on the apical side is observed and measured.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biopsy
  • Colon / metabolism*
  • Colonoscopy
  • Humans
  • In Vitro Techniques
  • Mice
  • Mucus / metabolism*
  • Rats