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, 25 (1), 1-6

Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test

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Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test

Yong Ku Han et al. Korean J Pain.

Abstract

Background: Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model of inflammatory pain.

Methods: Male Sprague Dawley rats were prepared for intrathecal catheterization. Pain was evoked by injection of formalin solution (5%, 50 µl) into the hind paw. Curcumin doses of 62.5, 125, 250, and 500 µg were delivered through an intrathecal catheter to examine the flinching responses. The ED(50) values (half-maximal effective dose) with 95% confidence intervals of curcumin for both phases of the formalin test were calculated from the dose-response lines fitted by least-squares linear regression on a log scale.

Results: In rats with intrathecal administration of curcumin, the flinching responses were significantly decreased in both phases. The slope of the regression line was significantly different from zero only in phase 2, and the ED(50) value (95% confidence interval) of curcumin was 511.4 µg (23.5-1126.5). There was no apparent abnormal behavior following the administration of curcumin.

Conclusions: Intrathecal administration of curcumin decreased inflammatory pain in rats, and further investigation to elucidate the precise mechanism of spinal action of curcumin is warranted.

Keywords: antinociception; curcumin; formalin test; spinal cord.

Figures

Fig. 1
Fig. 1
Time course of intrathecal curcumin on flinching response during the formalin test. Curcumin was administered 10 min before the formalin injection. Data are presented as the mean of the number of flinches ± SEM of 5 rats at each time point.
Fig. 2
Fig. 2
Dose-response curves of intrathecal curcumin on flinching response during phase 1 (A) and phase 2 (B) in the formalin test. Curcumin was administered 10 min before the formalin injection. Data are presented as the percentage of control. Each line represents mean ± SEM of 5 rats. Compared with control, *P < 0.05.

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References

    1. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa) J Altern Complement Med. 2003;9:161–168. - PubMed
    1. Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 1991;51:813–819. - PubMed
    1. Oetari S, Sudibyo M, Commandeur JN, Samhoedi R, Vermeulen NP. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Biochem Pharmacol. 1996;51:39–45. - PubMed
    1. Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 1995;55:259–266. - PubMed
    1. Sharma S, Kulkarni SK, Agrewala JN, Chopra K. Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pharmacol. 2006;536:256–261. - PubMed

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