Comparison of perinatal outcome after pre-viable preterm prelabour rupture of membranes in two centres with different rates of termination of pregnancy

BJOG. 2012 Mar;119(4):449-57. doi: 10.1111/j.1471-0528.2011.03265.x. Epub 2012 Jan 20.


Objective: To assess perinatal outcomes after expectant management in the case of preterm prelabour rupture of membranes (PPROM) before 25 weeks of gestation, according to the rate of termination of pregnancy (TOP).

Design: Retrospective comparative cohort study.

Population: Singleton pregnancies complicated by PPROM between 15(0/7) and 24(6/7) weeks of gestation, from January 2003 to January 2007.

Methods: Comparison of perinatal outcomes in two French tertiary care referral centres presumed to have different rates of TOP.

Main outcome measure: Rates of TOP, survival and survival without major morbidity.

Results: A total of 113 women experienced PPROM (49 in centre A and 64 in centre B). A lower proportion of patients opted for TOP in centre A (40.8%) than in centre B (56.3%). The baseline characteristics of patients and pregnancies, and gestational age at PPROM, were not different between the two centres. Mean gestational age at delivery (28.1 versus 25.4 weeks of gestation; P < 0.01), mean latency period (45.5 versus 16.1 days; P < 0.01), mean birthweight (1295 versus 929 g; P = 0.04) and survival (46.9 versus 20.3%; P < 0.01) were significantly higher in centre A than in centre B. The percentage of neonates alive without major morbidity was also higher in centre A than in centre B (42.9 versus 20.3%; P = 0.01).

Conclusions: Perinatal outcomes of pregnancies managed expectantly were not better in the centre where the TOP rate was higher. The perinatal risk of pregnancies complicated by pre-viable PPROM remains high.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Abortion, Induced / statistics & numerical data*
  • Adult
  • Algorithms
  • Cohort Studies
  • Delivery, Obstetric / statistics & numerical data
  • Female
  • Fetal Membranes, Premature Rupture / epidemiology*
  • Fetal Membranes, Premature Rupture / etiology
  • Fetal Membranes, Premature Rupture / mortality
  • Fetal Mortality*
  • France / epidemiology
  • Gestational Age
  • Hospitals, Maternity
  • Hospitals, University
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / epidemiology
  • Perinatal Mortality*
  • Pregnancy
  • Pregnancy Complications / epidemiology
  • Pregnancy Outcome
  • Retrospective Studies
  • Survival Rate
  • Time Factors