Reliability and repeatability of swept-source Fourier-domain optical coherence tomography and Scheimpflug imaging in keratoconus

J Cataract Refract Surg. 2012 Mar;38(3):485-94. doi: 10.1016/j.jcrs.2011.10.027. Epub 2012 Jan 20.


Purpose: To evaluate the repeatability and reliability of a recently introduced swept-source Fourier-domain anterior segment optical coherence tomography (AS-OCT) system and a high-resolution Scheimpflug camera and to assess the agreement between the 2 instruments when measuring healthy eyes and eyes with keratoconus.

Setting: Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

Design: Evaluation of diagnostic test or technology.

Methods: Three consecutive series of anterior segment images were taken with AS-OCT (Casia SS-1000) followed by rotating Scheimpflug imaging (Pentacam high resolution). Axial keratometry in the steep and flat meridians and astigmatism values were recorded. Pachymetry in the apex, center, and the thinnest position and anterior chamber depth (ACD) measurements were also taken.

Results: This study enrolled 57 healthy volunteers (57 eyes) and 56 patients (84 eyes) with keratoconus. Significant difference was found in all measured anterior segment parameters between normal eyes and keratoconic eyes (P<.05). In keratoconic eyes, the difference between repeated measurements was less with AS-OCT than with Scheimpflug imaging in every keratometry and astigmatism value, in apical thickness, and in ACD. For keratometry, the thinnest and central pachymetry measurement repeatability was better in healthy eyes than in keratoconic eyes with both instruments. In general, the mean difference between AS-OCT and Scheimpflug imaging was higher in cases of keratoconus.

Conclusions: Significant differences in keratometry, pachymetry, and ACD results were found between AS-OCT and Scheimpflug imaging. However, the repeatability of the measurements was comparable.

Financial disclosure: No author has a financial or proprietary interest in any material or method mentioned.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Anterior Eye Segment / pathology*
  • Diagnostic Techniques, Ophthalmological*
  • Female
  • Fourier Analysis
  • Humans
  • Keratoconus / diagnosis*
  • Male
  • Photography / instrumentation*
  • Refraction, Ocular / physiology
  • Reproducibility of Results
  • Tomography, Optical Coherence / instrumentation*
  • Visual Acuity / physiology