Dynamic contrast-enhanced magnetic resonance imaging-derived kep as a potential biomarker of matrix metalloproteinase 9 expression in patients with glioblastoma multiforme: a pilot study

J Comput Assist Tomogr. Jan-Feb 2012;36(1):125-30. doi: 10.1097/RCT.0b013e31823f6c59.


Objective: To look for the association of tissue matrix metalloproteinase 9 (MMP-9) expression with dynamic contrast-enhanced magnetic resonance imaging and to see whether these can prognosticate patients with glioblastoma multiforme (GBM).

Methods: Forty-seven patients with GBM underwent dynamic contrast-enhanced magnetic resonance imaging to look for association of its indices with tissue MMP-9 expression using Pearson correlation. Kaplan-Meier survival analysis was performed to study the survival pattern for low-, medium-, and high-tissue MMP-9 expression and kep values.

Results: Among perfusion indices, kep, k, and ve significantly correlated with MMP-9 expression. Matrix metalloproteinase 9 expression was found to be best estimated by kep using a quadratic model. The 1-year survival in low-, medium-, and high-tissue MMP-9 and kep groups were 59%, 45%, and 7%, and 59%, 33%, and 15%, respectively.

Conclusion: The association of kep and MMP-9 expression with survival suggests that kep may be used as imaging biomarker of GBM progression and its prognostication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism*
  • Brain Neoplasms / metabolism*
  • Contrast Media
  • Disease Progression
  • Female
  • Glioblastoma / metabolism*
  • Humans
  • Immunoenzyme Techniques
  • Magnetic Resonance Imaging / methods
  • Male
  • Matrix Metalloproteinase 9 / metabolism*
  • Middle Aged
  • Pilot Projects
  • Predictive Value of Tests
  • Survival Analysis


  • Biomarkers, Tumor
  • Contrast Media
  • Matrix Metalloproteinase 9