Selective ozone concentrations may reduce the ischemic damage after a stroke

Free Radic Res. 2012 May;46(5):612-8. doi: 10.3109/10715762.2012.659247. Epub 2012 Feb 14.


Abstract Stroke is one of the most debilitating diseases, and it is unfortunate that only a small percentage of patients can be treated with thrombolytic agents. Consequently, there is an urgent need of finding an alternative procedure for reoxygenating the so-called penumbra at the earliest time as possible for reducing morbidity and disability. A preliminary, preclinical study has been carried out by using rat hippocampal and cortical brain slices subjected to oxygen-glucose deprivation. Oxygen-ozone gaseous mixture appeared to be effective in reverting damage of brain tissues, supporting the evaluation of this approach in well-designed clinical trials in stroke patients.

MeSH terms

  • Animals
  • Cerebellum / blood supply
  • Cerebellum / pathology
  • Hippocampus / blood supply
  • Hippocampus / pathology
  • Hypoxia-Ischemia, Brain / drug therapy*
  • Hypoxia-Ischemia, Brain / pathology
  • In Vitro Techniques
  • Oxygen / therapeutic use
  • Ozone / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species
  • Stroke / drug therapy*
  • Stroke / pathology


  • Reactive Oxygen Species
  • Ozone
  • Oxygen