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. 2012;14(1):39-45.
doi: 10.1080/10286020.2011.622719.

1,4-Dioxane and ergosterol derivatives from Withania somnifera roots

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1,4-Dioxane and ergosterol derivatives from Withania somnifera roots

Laxminarain Misra et al. J Asian Nat Prod Res. 2012.

Abstract

The chemical investigation on the n-hexane extract of Withania somnifera roots has yielded octacosane, oleic and stearic fatty acids, stigmasterone, stigmasterol, sitostanone, oleanolic acid along with the ergosterol and 1,4-dioxane derivatives as new compounds. The isolation of alkenyl-1,4-dioxane compound is rare, whereas the ergosterol derivative may have biogenetic significance in the lactone formation in the E ring of withanolides. The presence of a 1,4-dioxane derivative in the nonpolar extract of roots assumes importance as this type of compound has not been reported earlier from W. somnifera. The structures of new compounds were elucidated by spectroscopic methods and chemical transformations.

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