Centromeres poised en pointe: CDKs put a hold on CENP-A assembly

Kaitlin M Stimpson; Beth A Sullivan

doi:10.1016/j.devcel.2011.12.013

Centromeres poised en pointe: CDKs put a hold on CENP-A assembly

Dev Cell. 2012 Jan 17;22(1):1-2. doi: 10.1016/j.devcel.2011.12.013.

Authors

Kaitlin M Stimpson¹, Beth A Sullivan

Affiliation

¹ Institute for Genome Sciences & Policy, Duke University School of Medicine, Durham, NC 27708, USA.

PMID: 22264723
DOI: 10.1016/j.devcel.2011.12.013

Abstract

Eukaryotic centromeres are propagated by incorporation of the centromere-specific histone CENP-A into centromeric chromatin. Silva et al. (2012) now show that cyclin-dependent kinases (CDKs) hold the CENP-A assembly machinery in an inactive state until mitotic exit and entry into G1, at which time new CENP-A is loaded.

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